Randomized controlled trial of standard versus high-dose intravenous omeprazole after endoscopic therapy in high-risk patients with acute peptic ulcer bleeding.
Chan WH; Khin LW; Chung YF; Goh YC; Ong HS; Wong WK
Department of Surgery, Singapore General Hospital, National Heart Centre Singapore, Singapore, Republic of Singapore. gsucwh@sgh.com.sg.
BACKGROUND:
Rebleeding from peptic ulcers is a major contributor to death. This study compared standard (40-mg intravenous infusion of omeprazole once daily for 3 days) and high-dose (80-mg bolus of omeprazole followed by 8-mg/h infusion for 72 h) in reducing the rebleeding rate (primary endpoint), need for surgery, duration of hospital stay and mortality in patients with peptic ulcer bleeding after successful endoscopic therapy.
METHODS:
This was a single-institution prospective randomized controlled study based on a postulated therapeutic equivalence of the two treatments. All patients who had successful endoscopic haemostasis of a bleeding peptic ulcer (Forrest classification Ia, Ib, IIa or IIb) were recruited. Informed consent was obtained and patients were randomized to receive standard- or high-dose infusions of intravenous omeprazole.
RESULTS:
Two (3 per cent) of 61 patients in the high-dose group and ten (16 per cent) of 61 in the standard-dose group exhibited rebleeding, a difference of - 13 (95 per cent confidence interval - 25 to - 2) per cent. The upper limit of the one-sided confidence interval exceeded a predefined equivalence absolute difference of 16 per cent. Equivalence of standard- and high-dose omeprazole in preventing rebleeding was not demonstrated.
CONCLUSION:
Intravenous standard-dose omeprazole was inferior to high-dose omeprazole in preventing rebleeding after endoscopic haemostasis for peptic ulcer bleeding. Registration number: NCT00519519 (http://www.clinicaltrials.gov). Copyright © 2011 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
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regann
Wed 11 May 2011 6:32 AM
I'm sure sitting all the time isn't good for us, but all this romanticization of how much healthier life was when people worked on their feet all day is heinous. I'm the first desk worker in my family, so I've been around people all my life who have the standing jobs. My mom worked all day in a textile mill and a job like that puts tremendous stress on your body -- she had tendinitis, plantar fasciitis, hemorrhoids, back issues, not to mention a slew of other problems that I can't remember off the top of my head. Point is, the working on her feet for 15 years left my mom completely bedridden by the time she was 40, so I'm really not buying how much greater it is to stand all day.
And LOL at the 'we weren't fat when we worked in fields/factories a hundred years ago' trope. People also didn't have access to enough food and usually spent their whole lives malnourished and vitamin-deprived, but that's so much better than being overweight! (Edit comment)
zegota
promoted by regann
This. I think people (me included, definitely) should be encouraged to walk around a little every hour, as it seems clear from the science that's pretty healthy. I've yet to see a study that standing 8-10 hours a day is great for your health, though. (Edit comment)
Tethtibis Deseidhr
promoted by regann
I feel really bad for all of those in wheelchairs who CAN'T stand up. according to this, their life expectancy is 15 more years....
yeah, not buying it. (Edit comment)
Kamatari +
They also didn't have access to cost cutting-bad-for-you additives such as High fructose corn syrup. Anywho, the point is sitting down being bad for you is true non the less. I wouldn't suggest standing all day; a healthy balance of some movement throughout the day does do much better than hours of sitting. (Edit comment)
geeky_reader
promoted by regann
I'm not buying into the standing cult either. I agree that sitting isn't the ideal thing to do for prolonged periods of time, however, I'm not sure if it's less harmful than a physically demanding job.
My mother worked at retail stores for the majority of my childhood. I remember her almost constant pain from being on her feet all day, on top of getting to and from the bus stop as part of her commute. I deal with a lot of crap at my desk job, but at least I don't have physical reminders of how much working sucks. I am in fact not just grateful but relieved that I am comfortable while cranking out code. I embrace the wimpiness.
My father worked in the coal mines for several years. I'd say if it wasn't for the lung problems that come with working in the mine, that job would have been the best possible for him. I think he probably put in 6 miles a day which is probably better than a retail job since the majority of time spent on his feet was used for walking rather than standing. (Edit comment)
regann
I agree that moderation is key but this infographic is singing the praises of working in a field or factory all day which I think we can all agree sucks and is not the idyll it's presented as. (Edit comment)
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